Imaging during stereotactic and functional neurosurgery

The overall aim of the project is to improve imaging protocols and logistics for MRI and CT during stereotactic and functional neurosurgery and to use these sequences for identification of tissue type and anatomy. This will be done along trajectories towards deep brain structures (e.g. globus pallidus internus and the subthalamic nucleus) and at borders between tumors and healthy tissue. The stereotactic MR/CT imaging data will be compared and related to optical data (laser Doppler perfusion monitoring and reflections spectroscopy) captured along trajectories during implantation of deep brain stimulation electrodes. The images will also form the base for computer simulations of the electrical field generated by deep brain stimulation electrodes. Furthermore MR images and MR spectra will be recorded post-operatively to tumor resection and used for comparison with fluorescence data captured along the border zone during the surgical resection. The imaging project is a part of a larger project with the overall aim of improving navigation and intervention in neurosurgery, see also http://www.imt.liu.se/bit/neuroengineering/

• Staff:

Karin Wårdell , Prof		Projekt Manager		IMT/Biomedical Instrumentation
Peter Lundberg , Assoc. prof.				IMV/Radiation Physics
Johan Richter , MD				Neurosurgery
Peter Zsigmond , MD				Neurosurgery
Anders Tisell , MSc		grad student		IMV
Olof Dahlqvist , MSc		grad student		IMV

• Former Staff:

• Project Description:

The overall aim of the project is to improve imaging protocols and logistics for routine MRI and CT during stereotactic and functional neurosurgery and to use these sequencies for identification of tissue type in conjunction to optical measurements during deep brain stimulation (DBS) electrode implantation, biopsy and tumour resection.  In relation to optical investigations during extirpation of tumours, also protocols for MR spectroscopy is of importance.